Bioidentical vs Synthetic Hormone Replacement Therapy

Let’s take a closer look at the core differences between synthetic and bio-identical hormones. From the microscopic structural differences to the impact on the body’s recognition and processing at receptor sites, these two hormonal approaches are vastly different. If you have been seeking clarity on the choices available in hormone replacement therapy, then here’s the scoop…

Bioidentical vs Synthetic

Molecular Mojo vs. Disrupted Hormones:

Bio-identical hormones are just that… exactly the hormones that are made by our bodies. This mirroring of the molecular structures offers seamless integration of supplemented hormones and guarantee recognition by our biological systems.

On the other hand, synthetic hormones, are not exact copies of what we make. Slight differences in molecular structures are picked up by the body. And while these might be somewhat effective in addressing symptoms, these tiny differences make these synthetic products to be recognized as foreigners in the body and they ultimately disrupt the delicate hormonal balance.

Custom Tailoring vs. One-Size-Fits-All:

Synthetic hormones offered by the big pharma companies of the world are one-size-fits-all, to an extent. They are designed to stop symptoms. Their long-term overarching purposes are not a focus for these drug manufacturers.

Bio-identical hormone replacement therapy offers a personalized approach. These formulas can be tailored to each individual woman’s unique hormonal profile. By doing this, BHRT aims to replenish hormonal deficiencies precisely, which enables you to take the exact right dosage for you in each stage of life.

Body’s Recognition vs. Potential Risks:

Synthetic hormones, while effective in addressing menopausal symptoms, may carry certain risks due to their distinct molecular structures.

Our bodies have evolved to recognize and metabolize bio-identical hormones efficiently. This recognition promotes a more natural integration, potentially reducing the risk of adverse effects.

So, never, ever, ever would
I ever, ever, ever
recommend that anyone
swallow estrogen.
(synthetic OR bioidentical)
A patch or transdermal
cream works superbly, so
there’s no reason for it.
Ever. Never……… NEVER.

Synthetic Hormones – The Bad

Synthetic hormones, owing to their distinct molecular structures, may pose certain risks that stem from their differences compared to naturally occurring hormones. Here are some examples:

Increased Risk of Blood Clots: Synthetic hormones, especially those found in traditional hormone replacement therapy (HRT), have been associated with an elevated risk of blood clot formation. This can be particularly concerning as blood clots can lead to serious conditions such as deep vein thrombosis or pulmonary embolism.

Cardiovascular Concerns: Some studies have suggested a potential link between synthetic hormone use and an increased risk of cardiovascular issues. This includes conditions such as heart attacks and strokes, which may be influenced by the impact of synthetic hormones on the vascular system.

Breast Cancer Risk: The Women’s Health Initiative (WHI) study raised concerns about the use of synthetic hormones, particularly the combination of synthetic estrogen and progestin, and its potential association with an increased risk of breast cancer. This has led many women to seek alternative hormone replacement options, like bioidentical therapies.

Uterine Health: The use of synthetic progestins, a component of traditional HRT, has been linked to changes in the uterine lining. Continuous exposure to synthetic progestins may lead to abnormal cell growth, potentially increasing the risk of conditions such as endometrial hyperplasia.

Metabolic Effects: Synthetic hormones may influence metabolic processes in ways that differ from the body’s natural hormones. This can impact factors such as insulin sensitivity and lipid profiles, potentially contributing to metabolic imbalances and insulin resistance.

Mood and Mental Health: Hormones play a crucial role in mood regulation, and the introduction of synthetic hormones may affect neurotransmitter activity. Some women report mood swings, anxiety, or depression as side effects of synthetic hormone use.

It’s essential to note that individual responses to synthetic hormones can vary, and not every woman will experience these risks. However, these examples underscore the importance of considering the potential drawbacks associated with the use of synthetic hormones in hormone replacement therapy.

What are synthetic hormones?
How do I know if I am taking a synthetic?

All birth control pills are synthetic.

Synthetic Progestins: (not progesterone)
== Provera (medroxyprogesterone acetate), Aygestin (norethindrone), Megace (megestrol), Levonorgestrel, drospirenone, norgestrel, etonogestrel

Synthetic Estrogens: Premarin is Conjugated Equine Estrogen (CEE) and is made from the urine of pregnant mares.

<Yes, it is from horse pee.> Anything that says conjugated estrogens, esterified estrogens, delestrogen.There are commercially available estrogens that are bioidentical. However, these come with a few caveats, themselves. Estrace (estradiol) tablets are bioidentical estrogens. But… they are swallowed. This is an oral dosage form. This has to be absorbed, goes to the liver for processing before getting to the intended sites of action. In the processing that takes place in the liver, we get some metabolites formed. These metabolites are responsible for the increased risk of cancer, clots, strokes, etc.

So, never, ever, ever would I ever, ever, ever recommend that anyone swallow estrogen.

A patch or transdermal cream works superbly, so there’s no reason for it. Ever. Never……. NEVER.

Bioidentical HRT – The Beautiful

Beyond Symptom Relief: The Holistic Benefits

BHRT stands out as a multifaceted approach to women’s health, extending beyond symptom relief to address broader age-related concerns. Here’s a look at some of the holistic benefits of BHRT:

Mind Boost (Neuroprotective Effects): BHRT, particularly when addressing hormonal imbalances associated with menopause, has been linked to neuroprotective effects. Some studies suggest that maintaining hormonal balance through BHRT may contribute to cognitive health, reducing the risk of conditions like Alzheimer’s, Parkinson’s and dementia. You know that brain fog that you’ve started noticing? It could be from declining estrogen or hormone imbalance in general.

Heart Happy (Cardiovascular Health): Hormones play a vital role in cardiovascular health, influencing factors such as blood vessel function and cholesterol levels. BHRT, when tailored to your individual needs, support heart health by maintaining a more favorable hormonal balance, potentially reducing the risk of cardiovascular diseases.

Bone Bliss (Bone Health and Osteoporosis Prevention): Hormonal fluctuations, especially the decline in estrogen during menopause, can impact bone density. BHRT, by providing bio-identical forms of hormones like estrogen, helps in preserving bone health and reducing the risk of osteoporosis, a common concern for postmenopausal women.

Breast Guardian (Breast Health): Unlike synthetic hormones that have raised concerns about breast cancer Many studies show that bio-identical hormones do not pose the same risks and could even have protective effects on breast tissue.

Mood Magic (Mood and Emotional Well-Being): BHRT, by restoring hormonal balance, can positively influence mood and emotional well-being. Women often report improvements in mood, reduced anxiety, and an overall sense of well-being when undergoing BHRT tailored to their specific needs.

Life Upgrade (Quality of Life): A well-balanced hormonal profile achieved through BHRT has the potential to enhance the overall quality of life for women in various aspects. This may include improved energy levels, better sleep, enhanced libido, and a more positive outlook on life.

Metabolic Harmony (Balance): Hormones play a role in metabolic processes, including insulin sensitivity and body composition. BHRT may support metabolic balance, helping women maintain a healthy weight and reduce the risk of metabolic disorders associated with aging.

Your Personal Recipe (Individualized Approach): One of the key strengths of BHRT is its personalized and individualized approach. Hormone therapy is tailored to each woman’s unique hormonal needs, ensuring a more precise and targeted treatment strategy.

What are bioidentical hormones? How do I know if I am taking a bioidentical?

Prometrium (progesterone) is bioidentical. Unlike estrogens, it is GLORIOUS when you swallow it… because, the metabolites generated through liver metabolism stimulate the GABA receptors which means they help with mood, depression, anxiety, sleep.

Most estrogen patches are 17beta-estradiol, which is bioidentical. Other bioidenticals are commonly made by compounding pharmacies.

*****The dosage form that is the safest and is the most recommended by the American Academy of Anti-Aging and Functional Medicine is transdermal estrogen. It is called Biest (because it has 2 different forms of estrogen in it). You apply to the skin and rub in. Hormones are lipophilic, which means they cross the barrier of the skin very readily. Other dosage forms might include sublingual tablets that are dissolved under the tongue. However, they don’t dissolve rapidly and you end up swallowing most of it, these are then considered oral dosage forms and do we ever, ever, ever take oral estrogen? Never. NEVER EVER EVER. *****

You may be wondering: I have seen compounded prescriptions ordered for Bioidentical hormones but they want them in a capsule. Is this Ok?

Remember… even if it is bioidentical, we NEVER, EVER, NEVER, EVER swallow estrogen.

It’s important to consult with a healthcare professional experienced in BHRT to assess individual health needs and create a personalized plan that considers the holistic well-being of each woman. BHRT, when used thoughtfully, has the potential to be a valuable tool in promoting immediate relief as well as long-term health and vitality.

You deserve to be offered the right hormone replacement therapy,

which is safe for you and effective for protecting your body.

You don’t have to just put up with symptoms.

When you know better, you do better.